Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | MMP3 | P08254 | 1/20 | 0.60 |
| ▸ | MMP7 | P09237 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9228437 | 0.94 | ALDH1A1 (0.71) | GLAALDH1A1GAALMNAKMT2A | |
| SCHEMBL2372012 | 0.86 | KDM4E (0.61) | GLAALDH1A1GAALMNAKMT2A | |
| SCHEMBL12792918 | 0.83 | ALDH1A1 (0.64) | GLAALDH1A1GAALMNAKMT2A | |
| Bicarbonate SCHEMBL15225914 | 0.82 | SMN1; SMN2 (0.70) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL12792936 | 0.81 | ALDH1A1 (0.65) | GLAALDH1A1GAALMNAKMT2A | |
| Bicarbonate SCHEMBL15226050 | 0.80 | MEN1 (0.63) | GLAALDH1A1GAALMNAKMT2A | |
| SCHEMBL7354199 | 0.80 | SMN1; SMN2 (0.61) | GLAALDH1A1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7354194 | 0.80 | SMN1; SMN2 (0.61) | GLAALDH1A1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7354188 | 0.80 | SMN1; SMN2 (0.61) | GLAALDH1A1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7377489 | 0.80 | SMN1; SMN2 (0.61) | GLAALDH1A1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1616859-B1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU KOGYO CO LTD (JP) | 2013-09-04 | — | — | EP | claimed |