Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634765 | 0.86 | MAPT (0.43) | ABCB1MAPTLMNAL3MBTL1RAB9A | |
| SCHEMBL27634759 | 0.84 | MAPT (0.43) | MAPTLMNAL3MBTL1ALDH1A1TSHR | |
| SCHEMBL6032170 | 0.84 | MAPT (0.43) | MAPTLMNAL3MBTL1ALDH1A1TSHR | |
| SCHEMBL2065476 | 0.83 | ELANE (0.54) | ABCB1MAPTLMNAL3MBTL1DRD2 | |
| SCHEMBL30070813 | 0.83 | ELANE (0.54) | ABCB1MAPTLMNAL3MBTL1DRD2 | |
| SCHEMBL27634737 | 0.81 | MAPT (0.45) | MAPTLMNAL3MBTL1RAB9APTPN1 | |
| SCHEMBL2865657 | 0.77 | EGFR (0.40) | MAPTLMNAL3MBTL1ALDH1A1PTPN1 | |
| SCHEMBL2867402 | 0.76 | EGFR (0.39) | MAPTLMNAL3MBTL1RAB9AALDH1A1 | |
| SCHEMBL2857509 | 0.76 | EGFR (0.39) | MAPTLMNAL3MBTL1RAB9AATM | |
| SCHEMBL2859896 | 0.76 | EGFR (0.39) | MAPTLMNAL3MBTL1TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1642880-B1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| CN-100567242-C | Hsp90 family protein blockers | KYOWA HAKKO KOGYO KK (JP) | 2009-12-09 | — | — | CN | disclosed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | disclosed |