Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634759 | 0.85 | MAPT (0.43) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL27634765 | 0.85 | MAPT (0.43) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL15225636 | 0.84 | ABCB1 (0.43) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL2859896 | 0.83 | EGFR (0.39) | MAPTMAPK1KDM4EHSD17B10LMNA | |
| SCHEMBL30070813 | 0.74 | ELANE (0.54) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL2065476 | 0.74 | ELANE (0.54) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL2865657 | 0.74 | EGFR (0.40) | MAPTMAPK1KDM4EHSD17B10LMNA | |
| SCHEMBL15225637 | 0.73 | LMNA (0.48) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL2857509 | 0.73 | EGFR (0.39) | MAPTMAPK1KDM4EHSD17B10LMNA | |
| SCHEMBL2867402 | 0.73 | EGFR (0.39) | MAPTMAPK1KDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100567242-C | Hsp90 family protein blockers | KYOWA HAKKO KOGYO KK (JP) | 2009-12-09 | — | — | CN | disclosed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | disclosed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | disclosed |