Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | RAF1 | P04049 | 3/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.59 |
| ▸ | CDC7 | O00311 | 8/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 4/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | CDK9 | P50750 | 3/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.53 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15243774 | 0.89 | CDC7 (0.55) | MAPK1RAF1MAP2K1CDC7CDK2 | |
| SCHEMBL15243650 | 0.77 | CDC7 (0.53) | MAPK1CDC7CDK2MAPKAPK2CDK1 | |
| SCHEMBL15690360 | 0.77 | CDC7 (0.53) | MAPK1CDC7CDK2MAPKAPK2CDK1 | |
| SCHEMBL15243965 | 0.77 | CDC7 (0.53) | MAPK1CDC7CDK2MAPKAPK2CDK1 | |
| SCHEMBL6225030 | 0.74 | CDC7 (0.50) | MAPK1CDC7CDK2MAPKAPK2CDK1 | |
| SCHEMBL7837428 | 0.74 | MAP2K1 (1.00) | MAPK1RAF1MAP2K1CDK2CDK1 | |
| SCHEMBL29100882 | 0.73 | MAPKAPK2 (0.49) | MAPK1CDC7CDK2MAPKAPK2CDK1 | |
| SCHEMBL14493821 | 0.73 | CDC7 (0.49) | MAPK1CDC7CDK2MAPKAPK2CDK1 | |
| SCHEMBL3445086 | 0.71 | PKN1 (0.50) | MAPK1RAF1MAP2K1CDK1CDK5 | |
| SCHEMBL6223044 | 0.70 | MAPKAPK2 (0.61) | MAPK1CDC7CDK2MAPKAPK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577537-A1 | SUBSTITUTED BICYCLES AS HSET INHIBITORS | Merck Patent GmbH (DE) | 2025-07-02 | — | — | EP | disclosed |
| CN-120091998-A | Substituted bicyclic rings as HSET inhibitors | 默克专利股份公司 | 2025-06-03 | — | — | CN | disclosed |
| WO-2024042007-A1 | SUBSTITUTED BICYCLES AS HSET INHIBITORS | MERCK PATENT GMBH (DE) | 2024-02-29 | — | — | WO | disclosed |
| US-9394297-B2 | Amides as pim inhibitors | AMGEN INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394297-B2 | Amides as pim inhibitors | AMGEN INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394297-B2 | Amides as pim inhibitors | AMGEN INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2015-11-19 | — | — | US | disclosed |
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2015-11-19 | — | — | US | disclosed |
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2015-11-19 | — | — | US | disclosed |
| WO-2013130660-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013130660-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2013-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | PIM1, PIM3, PIM2 | MAPK1 54/4885RAF1 87/4885MAP2K1 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.