Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.49 |
| ▸ | CDC7 | O00311 | 9/20 | 0.49 |
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.49 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15690360 | 0.73 | CDC7 (0.53) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL15230864 | 0.73 | MAPK1 (0.59) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL15243650 | 0.73 | CDC7 (0.53) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL15243965 | 0.73 | CDC7 (0.53) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL6225030 | 0.70 | CDC7 (0.50) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL14493821 | 0.69 | CDC7 (0.49) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL6223604 | 0.67 | CDC7 (0.43) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL4767679 | 0.66 | MAPKAPK2 (1.00) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL6223274 | 0.65 | CDC7 (0.42) | MAPKAPK2CDC7CDK9CDK2CLK4 | |
| SCHEMBL31607736 | 0.65 | PLK4 (0.49) | MAPKAPK2CDC7CDK9CDK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981667-A | Heterocyclic inhibitors of EGFR and/or HER2 for cancer treatment | 蝎子疗法股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| EP-4225445-A2 | HETEROCYCLIC INHIBITORS OF EGFR AND/OR HER2, FOR USE IN THE TREATMENT OF CANCER | Scorpion Therapeutics, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076831-A2 | METHODS FOR TREATING CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |