Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545612 | 0.90 | NAMPT (0.52) | NAMPTSMN1; SMN2HDAC1EPHX2NR1H4 | |
| SCHEMBL8590843 | 0.90 | SMN1; SMN2 (0.50) | NAMPTSMN1; SMN2HDAC1EPHX2NR1H4 | |
| SCHEMBL31652646 | 0.88 | HDAC1 (0.52) | NAMPTSMN1; SMN2HDAC1EPHX2NR1H4 | |
| SCHEMBL24383305 | 0.88 | NAMPT (0.47) | NAMPTSMN1; SMN2HDAC1L3MBTL1NPC1 | |
| SCHEMBL16444117 | 0.87 | NAMPT (0.47) | NAMPTSMN1; SMN2HDAC1EPHX2NR1H4 | |
| SCHEMBL6674215 | 0.84 | SMN1; SMN2 (0.50) | NAMPTSMN1; SMN2KMT2AHDAC6HDAC3 | |
| SCHEMBL23254754 | 0.84 | SMN1; SMN2 (0.50) | NAMPTSMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL4255873 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL8592267 | 0.83 | NAMPT (0.57) | NAMPTHDAC1EPHX2NR1H4L3MBTL1 | |
| SCHEMBL8237351 | 0.83 | NAMPT (0.57) | NAMPTHDAC1EPHX2NR1H4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328085-B2 | Heterocyclic compounds and expansion agents for hematopoietic stem cells | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2016-05-03 | — | — | US | disclosed |
| US-20130245255-A1 | HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245255-A1 | HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS | HCLS1, RUNX1, RCC1 | NAMPT 980/4885SMN1; SMN2 555/4885HDAC1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.