Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 19/20 | 0.72 |
| ▸ | EHMT1 | Q9H9B1 | 8/20 | 0.68 |
| ▸ | WHR1 | P49842 | 1/20 | 0.63 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.62 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15280519 | 0.92 | EHMT2 (0.68) | EHMT2EHMT1 | |
| SCHEMBL15280416 | 0.90 | EHMT2 (0.69) | EHMT2EHMT1 | |
| SCHEMBL15280402 | 0.88 | EHMT2 (0.63) | EHMT2EHMT1NSD2 | |
| SCHEMBL15280271 | 0.87 | EHMT2 (0.81) | EHMT2EHMT1WHR1NSD2EZH2 | |
| SCHEMBL15280596 | 0.87 | EHMT2 (0.69) | EHMT2EHMT1NSD2EZH2NSD3 | |
| SCHEMBL15280463 | 0.86 | EHMT2 (0.57) | EHMT2EHMT1WHR1 | |
| SCHEMBL15280468 | 0.86 | EHMT2 (0.56) | EHMT2EHMT1 | |
| SCHEMBL21486550 | 0.85 | EHMT2 (0.77) | EHMT2EHMT1 | |
| SCHEMBL21486547 | 0.85 | EHMT2 (0.77) | EHMT2EHMT1 | |
| SCHEMBL15280237 | 0.84 | EHMT2 (0.66) | EHMT2EHMT1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828250-B1 | QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2021-03-10 | — | — | EP | disclosed |
| US-9932317-B2 | Quinazoline compounds and their use in therapy | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-04-03 | — | — | US | disclosed |
| US-9932317-B2 | Quinazoline compounds and their use in therapy | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-04-03 | — | — | US | disclosed |
| US-20150057263-A1 | Quinazoline Compounds And Their Use In Therapy | IMPERIAL WHITE CITY INCUBATOR LIMITED (GB) | 2015-02-26 | — | — | US | disclosed |
| US-20150057263-A1 | Quinazoline Compounds And Their Use In Therapy | IMPERIAL WHITE CITY INCUBATOR LIMITED (GB) | 2015-02-26 | — | — | US | disclosed |
| WO-2013140148-A1 | QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL INNOVATIONS LIMITED (GB) | 2013-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057263-A1 | Quinazoline Compounds And Their Use In Therapy | EZH2, EHMT1, HNMT | EHMT2 4/4885EHMT1 2/4885WHR1 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.