Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 1/20 | 0.64 |
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.61 |
| ▸ | EHMT1 | Q9H9B1 | 7/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | CCR4 | P51679 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4113865 | 0.89 | TP53 (0.59) | WHR1EHMT2EHMT1CCR4 | |
| SCHEMBL15280598 | 0.89 | CCR4 (0.67) | WHR1EHMT2EHMT1CCR4 | |
| SCHEMBL15280268 | 0.88 | HRH4 (0.70) | WHR1EHMT2EHMT1CCR4 | |
| SCHEMBL22144612 | 0.85 | WHR1 (0.85) | WHR1EHMT2EHMT1CCR4 | |
| SCHEMBL3642962 | 0.84 | PDE5A (0.71) | EHMT2EHMT1 | |
| SCHEMBL15280238 | 0.83 | EHMT2 (0.65) | WHR1EHMT2CCR4 | |
| SCHEMBL15280408 | 0.81 | EHMT2 (0.64) | WHR1EHMT2HTR2ACCR4 | |
| SCHEMBL424718 | 0.80 | EHMT2 (0.52) | EHMT2EHMT1CCR4 | |
| SCHEMBL15280448 | 0.79 | CCR4 (0.61) | WHR1EHMT2EHMT1CCR4 | |
| SCHEMBL17122732 | 0.79 | KDM4E (0.70) | WHR1HTR2ACCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828250-B1 | QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2021-03-10 | — | — | EP | disclosed |
| US-9932317-B2 | Quinazoline compounds and their use in therapy | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-04-03 | — | — | US | disclosed |
| US-9932317-B2 | Quinazoline compounds and their use in therapy | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-04-03 | — | — | US | disclosed |
| US-20150057263-A1 | Quinazoline Compounds And Their Use In Therapy | IMPERIAL WHITE CITY INCUBATOR LIMITED (GB) | 2015-02-26 | — | — | US | disclosed |
| US-20150057263-A1 | Quinazoline Compounds And Their Use In Therapy | IMPERIAL WHITE CITY INCUBATOR LIMITED (GB) | 2015-02-26 | — | — | US | disclosed |
| WO-2013140148-A1 | QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL INNOVATIONS LIMITED (GB) | 2013-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057263-A1 | Quinazoline Compounds And Their Use In Therapy | EZH2, EHMT1, HNMT | WHR1 1384/4885EHMT2 4/4885EHMT1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.