Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | KRAS | P01116 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | ARAF | P10398 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | CSK | P41240 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24457818 | 0.78 | RAF1 (0.39) | ALDH1A1MAPTP2RX3P2RX2RAF1 | |
| SCHEMBL15263527 | 0.77 | RAF1 (0.38) | ALDH1A1RAF1MAPK8KRASBRAF | |
| SCHEMBL29699267 | 0.77 | RAF1 (0.38) | ALDH1A1RAF1MAPK8KRASBRAF | |
| SCHEMBL29427237 | 0.77 | RAF1 (0.38) | RAF1MAPK8KRASBRAFKDR | |
| SCHEMBL15263808 | 0.77 | RAF1 (0.38) | RAF1MAPK8KRASBRAFKDR | |
| SCHEMBL1942842 | 0.75 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4ESMN1; SMN2PDGFRB | |
| SCHEMBL15280809 | 0.74 | MEN1 (0.41) | ALDH1A1PRNPMAPTNPSR1RXFP1 | |
| SCHEMBL27103117 | 0.73 | MAPK8 (0.38) | P2RX3P2RX2MAPK8LRRK2 | |
| SCHEMBL22612761 | 0.70 | RAF1 (0.34) | RAF1MAPK8KRASBRAFKDR | |
| SCHEMBL27103170 | 0.68 | RAF1 (0.33) | RAF1MAPK8KRASBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334267-B2 | RAF inhibitor compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150119392-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC | 2015-04-30 | — | — | US | disclosed |
| US-8741911-B2 | Raf inhibitor compounds | ELI LILLY AND COMPANY (US) | 2014-06-03 | — | — | US | disclosed |
| US-20130252977-A1 | Raf Inhibitor Compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2013-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252977-A1 | Raf Inhibitor Compounds | BRAF, RAF1, ARAF | ALDH1A1 1870/4885PRNP 3973/4885MAPT 3515/4885 |
| US-20150119392-A1 | RAF INHIBITOR COMPOUNDS | BRAF, RAF1, NRAS | ALDH1A1 1552/4885PRNP 4105/4885MAPT 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.