Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.61 |
| ▸ | CCR5 | P51681 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15310659 | 0.87 | CCR2 (0.61) | CCR2CCR5KCNH2 | |
| SCHEMBL3734010 | 0.86 | CCR2 (0.66) | CCR2CCR5KCNH2 | |
| SCHEMBL3734008 | 0.85 | CCR2 (0.65) | CCR2CCR5KCNH2 | |
| SCHEMBL3733046 | 0.83 | CCR2 (0.70) | CCR2CCR5KCNH2 | |
| SCHEMBL3733041 | 0.83 | CCR2 (0.70) | CCR2CCR5KCNH2 | |
| SCHEMBL3733051 | 0.83 | CCR2 (0.70) | CCR2CCR5KCNH2 | |
| SCHEMBL15310601 | 0.83 | CCR2 (0.68) | CCR2CCR5KCNH2 | |
| SCHEMBL3739574 | 0.82 | CCR2 (0.77) | CCR2CCR5KCNH2 | |
| SCHEMBL3739577 | 0.82 | CCR2 (0.77) | CCR2CCR5KCNH2 | |
| SCHEMBL3739567 | 0.82 | CCR2 (0.77) | CCR2CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656345-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2013-10-16 | — | — | EP | disclosed |