Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 9/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15312051 | 0.91 | MAPKAPK5 (0.71) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9110359 | 0.91 | MAPKAPK5 (0.59) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL15311940 | 0.90 | MAPKAPK5 (0.48) | MAPKAPK5MAPKAPK2MAPK14MAPK1ROCK2 | |
| SCHEMBL9110025 | 0.88 | MAPKAPK2 (0.68) | MAPKAPK5MAPKAPK2MAPK14MAPK1ROCK2 | |
| SCHEMBL15311639 | 0.87 | MAPKAPK5 (0.45) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9111472 | 0.87 | MAPKAPK5 (0.59) | MAPKAPK5MAPKAPK2MAPK14MAPK1ROCK2 | |
| SCHEMBL16279619 | 0.87 | MAPKAPK5 (0.76) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL30514457 | 0.87 | MAPKAPK5 (0.76) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL15311731 | 0.86 | MAPKAPK5 (0.62) | MAPKAPK5MAPKAPK2MAPK14MAPK1ROCK2 | |
| SCHEMBL15311655 | 0.86 | MAPKAPK5 (0.43) | MAPKAPK5MAPKAPK2MAPK14MAPK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359300-B2 | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-06-07 | — | — | US | claimed |
| US-20130274272-A1 | METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2013-10-17 | — | — | US | claimed |
| US-9359300-B2 | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359300-B2 | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359300-B2 | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-20130274272-A1 | METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2013-10-17 | — | — | US | disclosed |
| US-20130274272-A1 | METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2013-10-17 | — | — | US | disclosed |
| US-20130274272-A1 | METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274272-A1 | METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | MAP3K1, MAPK1, PDXK | MAPKAPK5 44/4885MAPKAPK2 28/4885MAPK14 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.