Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2068306 | 0.95 | KCNH2 (0.82) | KCNH2CYP3A4TACR3CSNK1EP2RX7 | |
| SCHEMBL999379 | 0.94 | KCNH2 (1.00) | KCNH2CYP3A4CSNK1EP2RX7CSNK1D | |
| SCHEMBL2068840 | 0.90 | KCNH2 (0.80) | KCNH2CYP3A4TP53GAAMAPT | |
| SCHEMBL2068261 | 0.90 | KCNH2 (1.00) | KCNH2CYP3A4TP53CSNK1ECSNK1D | |
| SCHEMBL1000956 | 0.89 | KCNH2 (0.87) | KCNH2CYP3A4CSNK1EP2RX7CSNK1D | |
| SCHEMBL1044397 | 0.89 | KCNH2 (0.87) | KCNH2CYP3A4CSNK1ECSNK1DPDK2 | |
| SCHEMBL1050937 | 0.87 | KCNH2 (0.80) | KCNH2CYP3A4TACR3CSNK1EP2RX7 | |
| SCHEMBL12781873 | 0.86 | KCNH2 (0.82) | KCNH2CYP3A4GAAMAPTPDK2 | |
| SCHEMBL2069758 | 0.86 | KCNH2 (1.00) | KCNH2CYP3A4TACR3CSNK1EP2RX7 | |
| SCHEMBL2069186 | 0.86 | KCNH2 (0.84) | KCNH2CYP3A4MAPTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469645-B2 | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2016-10-18 | — | — | US | disclosed |
| US-20130281403-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | IRM LLC (BM) | 2013-10-24 | — | — | US | disclosed |
| US-8557801-B2 | Compounds and compositions useful for the treatment of parasitic diseases | IRM LLC (BM) | 2013-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281403-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | SQLE, ABCB1, FDPS | KCNH2 1679/4885CYP3A4 97/4885TP53 4077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.