Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | BAD | Q92934 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313740 | 0.90 | BCL2 (0.53) | BCL2MCL1BADAKR1C3GAA | |
| SCHEMBL15313739 | 0.89 | BCL2 (0.59) | BCL2MCL1BADAKR1C3MAPK1 | |
| SCHEMBL15313758 | 0.88 | BCL2 (0.63) | BCL2AKR1C3GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL15313741 | 0.87 | BCL2 (0.61) | BCL2MCL1BADAKR1C3MAPK1 | |
| SCHEMBL15313761 | 0.87 | BCL2 (0.57) | BCL2MCL1BADAKR1C3MAPK1 | |
| SCHEMBL15313766 | 0.87 | BCL2 (0.51) | BCL2MCL1BADAKR1C3GAA | |
| SCHEMBL15313737 | 0.86 | ALDH1A1 (0.58) | BCL2MCL1BADAKR1C3MAPK1 | |
| SCHEMBL15313736 | 0.86 | ALDH1A1 (0.58) | BCL2MCL1BADAKR1C3MAPK1 | |
| SCHEMBL15313764 | 0.86 | MEN1 (0.51) | BCL2MCL1BADAKR1C3MAPK1 | |
| SCHEMBL15313743 | 0.86 | BCL2 (0.58) | BCL2MCL1BADAKR1C3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |