Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455274 | 1.00 | HRH3 (0.55) | HRH3KCNH2HDAC4SSTR4FPR1 | |
| SCHEMBL12128172 | 1.00 | HRH3 (0.55) | HRH3KCNH2HDAC4SSTR4FPR1 | |
| SCHEMBL451266 | 1.00 | HRH3 (0.55) | HRH3KCNH2HDAC4SSTR4FPR1 | |
| SCHEMBL18828640 | 0.86 | HRH3 (0.52) | HRH3KCNH2HDAC4SSTR4SSTR1 | |
| SCHEMBL15797826 | 0.86 | HRH3 (0.52) | HRH3KCNH2HDAC4SSTR4SSTR1 | |
| SCHEMBL15805108 | 0.86 | HRH3 (0.52) | HRH3KCNH2HDAC4SSTR4SSTR1 | |
| SCHEMBL15805085 | 0.86 | HRH3 (0.52) | HRH3KCNH2HDAC4SSTR4SSTR1 | |
| SCHEMBL15797825 | 0.86 | HRH3 (0.52) | HRH3KCNH2HDAC4SSTR4SSTR1 | |
| SCHEMBL23550031 | 0.85 | HRH3 (0.58) | HRH3KCNH2HDAC4SSTR4FPR1 | |
| SCHEMBL27813823 | 0.84 | HRH3 (0.60) | HRH3KCNH2HDAC4SSTR4TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029381-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-05-12 | — | — | US | disclosed |
| EP-2805937-A1 | Cyclopropyl amide derivatives | AstraZeneca AB (SE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2253615-B1 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2014-07-09 | — | — | EP | disclosed |
| EP-2195293-B1 | CYCLOPTOPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2013-10-16 | — | — | EP | disclosed |