SCHEMBL15314754

SCHEMBL15314754

CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(N)s3)c3c(C(C)O)cccc32)c1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL356726 0.91 CCR4 (1.00) CCR4
SCHEMBL357718 0.83 CCR4 (1.00) CCR4
SCHEMBL357601 0.82 CCR4 (0.83) CCR4
SCHEMBL358255 0.81 CCR4 (0.80) CCR4
SCHEMBL356927 0.80 CCR4 (1.00) CCR4
SCHEMBL358395 0.80 CCR4 (1.00) CCR4
SCHEMBL357566 0.79 CCR4 (1.00) CCR4
SCHEMBL355885 0.78 CCR4 (1.00) CCR4
SCHEMBL358030 0.78 CCR4 (1.00) CCR4
SCHEMBL15314744 0.78 CCR4 (0.69) CCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2401270-B1 PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS GLAXO GROUP LTD (GB) 2013-10-16 EP disclosed