Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ANPEP | P15144 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29077049 | 1.00 | ALDH1A1 (0.52) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL1531738 | 1.00 | ALDH1A1 (0.52) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL3044859 | 1.00 | ALDH1A1 (0.52) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL13386099 | 1.00 | ALDH1A1 (0.52) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Hydrochloric Acid SCHEMBL1531689 | 0.98 | ALDH1A1 (0.51) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Hydrochloric Acid SCHEMBL1531688 | 0.98 | ALDH1A1 (0.51) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL20583647 | 0.91 | MME (0.50) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL20583644 | 0.91 | MME (0.50) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL20583645 | 0.91 | MME (0.50) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL8522871 | 0.91 | MME (0.50) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107921144-B | Aureostatin analogs and conjugate conjugates thereof with cell-binding molecules | 杭州多禧生物科技有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-116726190-A | Aureostatin analogs and conjugate conjugates thereof with cell-binding molecules | 杭州多禧生物科技有限公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-3261443-B1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIV RICE WILLIAM M (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-2292639-B1 | Tubulisine derivatives as anticancer drugs | KEMOTECH S R L (IT) | 2014-09-03 | — | — | EP | disclosed |
| US-8580820-B2 | Tubulysin compounds with high cytotoxicity, pharmaceutical compositions thereof, and method of use thereof | KEMTECH S.R.L. (IT) | 2013-11-12 | — | — | US | disclosed |
| US-20110200581-A1 | PHARMACEUTICAL COMPOSITIONS | KEMOTECH S.r.I (IT) | 2011-08-18 | — | — | US | disclosed |
| EP-2292639-A1 | Tubulisine derivatives as anticancer drugs | Kemotech S.r.l. (IT) | 2011-03-09 | — | — | EP | disclosed |
| EP-2174947-A1 | Bioactive pre-tubulysins and use thereof | Universität des Saarlandes (DE) | 2010-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110200581-A1 | PHARMACEUTICAL COMPOSITIONS | NR1H3, NR1H2, CCR8 | ALDH1A1 4425/4885THRB 240/4885CYP2C9 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.