Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29769081 | 0.91 | PDE1C (0.48) | PDE1CHDAC4KDM1APTGER3KDM2B | |
| SCHEMBL1365601 | 0.85 | PDE1C (0.44) | PDE1CHDAC4KDM1APTGER3KDM2B | |
| SCHEMBL23212079 | 0.84 | PDE1C (0.47) | QDPRPDE1CHDAC4KDM1APTGER3 | |
| SCHEMBL19868691 | 0.82 | PDE1C (0.45) | PDE1CHDAC4KDM1APTGER3KDM2B | |
| Hydrochloric Acid SCHEMBL21381782 | 0.82 | PDE1C (0.45) | QDPRPDE1CHDAC4KDM1APTGER3 | |
| Hydrochloric Acid SCHEMBL30567988 | 0.82 | PDE1C (0.45) | QDPRPDE1CHDAC4KDM1APTGER3 | |
| SCHEMBL27306565 | 0.81 | KDM1A (0.44) | PDE1CHDAC4KDM1ADRD2SLC6A4 | |
| SCHEMBL21876110 | 0.80 | PDE1C (0.44) | PDE1CHDAC4KDM1APTGER3KDM2B | |
| SCHEMBL21876109 | 0.80 | PDE1C (0.44) | PDE1CHDAC4KDM1APTGER3KDM2B | |
| SCHEMBL19868693 | 0.80 | PDE1C (0.41) | PDE1CHDAC4KDM1APTGER3KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | NFATC1, IL5, CD4 | QDPR 2647/4885PDE1C 4590/4885HDAC4 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.