Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 6/20 | 0.44 |
| ▸ | KDM1A | O60341 | 4/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21876109 | 1.00 | PDE1C (0.44) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL29769081 | 0.89 | PDE1C (0.48) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL19868691 | 0.81 | PDE1C (0.45) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL1365601 | 0.80 | PDE1C (0.44) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL15317630 | 0.80 | QDPR (0.50) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL19868677 | 0.80 | KDM1A (0.49) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL27306565 | 0.80 | KDM1A (0.44) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| SCHEMBL19868693 | 0.78 | PDE1C (0.41) | PDE1CKDM1APTGER3HDAC4CREBBP | |
| Hydrochloric Acid SCHEMBL30567988 | 0.78 | PDE1C (0.45) | PDE1CKDM1APTGER3HDAC4PDE2A | |
| Hydrochloric Acid SCHEMBL21381782 | 0.78 | PDE1C (0.45) | PDE1CKDM1APTGER3HDAC4PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200131142-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131142-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | NR1H4, NR1H2, NR1H3 | PDE1C 2271/4885KDM1A 4845/4885PTGER3 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.