Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19813088 | 0.84 | DRD1 (0.60) | DRD1HTR2CPRMT5WDR77HTR2A | |
| SCHEMBL32670712 | 0.84 | DRD1 (0.60) | DRD1HTR2CPRMT5WDR77HTR2A | |
| SCHEMBL30360712 | 0.84 | DRD1 (0.60) | DRD1HTR2CPRMT5WDR77HTR2A | |
| SCHEMBL19812914 | 0.84 | DRD1 (0.60) | DRD1HTR2CPRMT5WDR77HTR2A | |
| SCHEMBL30360710 | 0.84 | DRD1 (0.60) | DRD1HTR2CPRMT5WDR77HTR2A | |
| SCHEMBL19812912 | 0.84 | DRD1 (0.60) | DRD1HTR2CPRMT5WDR77HTR2A | |
| SCHEMBL30360721 | 0.83 | TAAR1 (0.51) | DRD1HTR2CADRA2ACYP2D6ADRA2B | |
| SCHEMBL30360691 | 0.83 | TAAR1 (0.51) | DRD1HTR2CADRA2ACYP2D6ADRA2B | |
| SCHEMBL19812923 | 0.83 | TAAR1 (0.51) | DRD1HTR2CADRA2ACYP2D6ADRA2B | |
| SCHEMBL30360729 | 0.83 | TAAR1 (0.51) | DRD1HTR2CADRA2ACYP2D6ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834233-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | Orion Corporation (FI) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150173-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | ORION CORPORATION (FI) | 2013-10-10 | — | — | WO | disclosed |