Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15319833 | 1.00 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL15319835 | 1.00 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL15319830 | 1.00 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL21569034 | 0.95 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL14855250 | 0.95 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL14854883 | 0.93 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL14854879 | 0.93 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL14854869 | 0.93 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL14854867 | 0.93 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL15319705 | 0.88 | EGFR (0.61) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833886-B1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASE INHIBITORS | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2020-08-12 | — | — | EP | claimed |
| US-9353062-B2 | Substituted quinolines as bruton's tyrosine kinases inhibitors | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2016-05-31 | — | — | US | claimed |
| US-20150057312-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2015-02-26 | — | — | US | claimed |
| EP-2833886-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HangzhouDeRenYuCheng Biotechnology Ltd. (CN) | 2015-02-11 | — | — | EP | claimed |
| WO-2013152135-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | ZHANG DAWEI (US) | 2013-10-10 | — | — | WO | claimed |
| EP-2833886-B1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASE INHIBITORS | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2020-08-12 | — | — | EP | disclosed |
| US-9353062-B2 | Substituted quinolines as bruton's tyrosine kinases inhibitors | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2016-05-31 | — | — | US | disclosed |
| US-20150057312-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2015-02-26 | — | — | US | disclosed |
| EP-2833886-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HangzhouDeRenYuCheng Biotechnology Ltd. (CN) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013152135-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | ZHANG DAWEI (US) | 2013-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057312-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | BTK, ABL1, LYN | EGFR 1627/4885ERBB2 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.