Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.40 |
| ▸ | BCL6 | P41182 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320905 | 0.93 | EGFR (0.40) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15323103 | 0.93 | EGFR (0.39) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15321742 | 0.93 | EGFR (0.39) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15320781 | 0.92 | BCL6 (0.46) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15321507 | 0.89 | EGFR (0.43) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15323803 | 0.88 | EGFR (0.44) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15320769 | 0.88 | EGFR (0.44) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15321049 | 0.88 | ULK1 (0.44) | EGFRBCL6ITKULK1ULK2 | |
| SCHEMBL15321535 | 0.88 | EGFR (0.43) | EGFRBCL6ITKBTKULK1 | |
| SCHEMBL15337527 | 0.88 | EGFR (0.43) | EGFRBCL6ITKBTKULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | Rigel Pharmaceuticals, Inc. (US) | 2015-02-11 | — | — | EP | claimed |
| WO-2013152198-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2013-10-10 | — | — | WO | claimed |