SCHEMBL15323229

SCHEMBL15323229

CCCCCC1OC1C/C=C/C/C=C/C/C=C/CCCC(=O)O

nearest known ligand 0.90

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.87
PPARG P37231 6/20 0.63
ALDH1A1 P00352 6/20 0.63
PPARD Q03181 5/20 0.63
PPARA Q07869 5/20 0.63
CYP19A1 P11511 3/20 0.63
L3MBTL1 Q9Y468 2/20 0.63
KDM4E B2RXH2 2/20 0.63
LMNA P02545 2/20 0.63
CYP3A4 P08684 2/20 0.63
FABP4 P15090 2/20 0.63
HPGD P15428 2/20 0.63
ALOX15 P16050 2/20 0.63
NR4A2 P43354 2/20 0.63
HSD17B10 Q99714 2/20 0.63
TDP1 Q9NUW8 2/20 0.63
AKR1C3 P42330 2/20 0.63
KMT2A Q03164 2/20 0.63
MEN1 O00255 1/20 0.63
USP2 O75604 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2511236 1.00 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL15323230 1.00 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL15377389 1.00 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL15335272 1.00 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL3754861 0.99 MAPT (0.85) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL3754858 0.99 MAPT (0.85) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL3752243 0.95 MAPT (0.79) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL2508939 0.95 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL15335332 0.95 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA
SCHEMBL2508938 0.95 MAPT (0.87) MAPTPPARGALDH1A1PPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117630349-A Biomarkers associated with male reproductive dysfunction and uses thereof 上海市生物医药技术研究院 2024-03-01 CN disclosed
US-20200200775-A1 OXIDIZED LIPIDS AS BIOMARKERS FOR NEUROPATHIC PAIN Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2020-06-25 US disclosed
US-10322118-B2 Compounds and methods for inhibiting Cif virulence factor TRUSTEES OF DARTMOUTH COLLEGE (US) 2019-06-18 US disclosed
US-20160206605-A1 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-07-21 US disclosed
US-20150246075-A1 METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT CHILDREN'S MEDICAL CENTER CORPORATION 2015-09-03 US disclosed
US-20150246075-A1 METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT CHILDREN'S MEDICAL CENTER CORPORATION 2015-09-03 US disclosed
US-9056085-B2 Methods for enhancing hematopoietic stem/progenitor cell engraftment CHILDREN'S MEDICAL CENTER CORPORATION (US) 2015-06-16 US disclosed
US-9056085-B2 Methods for enhancing hematopoietic stem/progenitor cell engraftment CHILDREN'S MEDICAL CENTER CORPORATION (US) 2015-06-16 US disclosed
US-20150045389-A1 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-02-12 US disclosed
WO-2013155047-A2 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR TRUSTEES OF DARTMOUTH COLLEGE (US) 2013-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150246075-A1 METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT HCLS1, MCL1, THPO MAPT 4738/4885PPARG 2546/4885ALDH1A1 92/4885
US-20160206605-A1 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR CFTR, NCF1, CFB MAPT 4882/4885PPARG 3326/4885ALDH1A1 3655/4885
US-10322118-B2 Compounds and methods for inhibiting Cif virulence factor CFTR, NCF1, CFB MAPT 4882/4885PPARG 3326/4885ALDH1A1 3655/4885
US-20150045389-A1 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR CFTR, NCF1, CFB MAPT 4882/4885PPARG 3180/4885ALDH1A1 3767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.