Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL8462550 | 0.91 | MEN1 (0.44) | PRCPMEN1BLMKMT2ADPP4 | |
| Succinic Acid SCHEMBL8462554 | 0.91 | MEN1 (0.44) | PRCPMEN1BLMKMT2ADPP4 | |
| Proline SCHEMBL15323738 | 0.88 | PRCP (0.41) | PRCPMEN1BLMKMT2ADPP7 | |
| Proline SCHEMBL15322641 | 0.86 | PRCP (0.39) | PRCPMEN1BLMKMT2ADPP7 | |
| Succinic Acid SCHEMBL15322642 | 0.86 | PRCP (0.39) | PRCPMEN1BLMKMT2ADPP7 | |
| Proline SCHEMBL28049461 | 0.85 | MEN1 (0.48) | PRCPMEN1BLMKMT2ADPP7 | |
| Proline SCHEMBL599791 | 0.84 | FFAR3 (0.46) | PRCPMEN1BLMKMT2ADPP7 | |
| Proline SCHEMBL599790 | 0.84 | FFAR3 (0.46) | PRCPMEN1BLMKMT2ADPP7 | |
| Alpha-Ketoglutaric Acid SCHEMBL6805961 | 0.83 | MAPK1 (0.48) | PRCPMEN1BLMKMT2ADPP7 | |
| Alpha-Ketoglutaric Acid SCHEMBL6805964 | 0.83 | MAPK1 (0.48) | PRCPMEN1BLMKMT2ADPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |