Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alpha-Ketoglutaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Ketoglutaric Acid SCHEMBL6805964 | 1.00 | MAPK1 (0.48) | MAPK1SLC13A3EGLN1OR51E2MEN1 | |
| Proline SCHEMBL8462550 | 0.91 | MEN1 (0.44) | MEN1BLMKMT2ADPP4DPP8 | |
| Succinic Acid SCHEMBL8462554 | 0.91 | MEN1 (0.44) | MEN1BLMKMT2ADPP4DPP8 | |
| Succinic Acid SCHEMBL15322642 | 0.86 | PRCP (0.39) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL15322641 | 0.86 | PRCP (0.39) | MEN1BLMKMT2ADPP4DPP8 | |
| Succinic Acid SCHEMBL15323281 | 0.83 | PRCP (0.42) | MEN1BLMKMT2ADPP4DPP8 | |
| Adipic Acid SCHEMBL16915303 | 0.82 | ARG1 (0.41) | MEN1BLMKMT2ADPP4DPP8 | |
| Adipic Acid SCHEMBL16915301 | 0.82 | ARG1 (0.41) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL18766240 | 0.81 | BLM (0.48) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL462226 | 0.81 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127413-A1 | Enteric keto acid and amino acid salts and their use for preparing medicines | AVAYA TECHNOLOGY LLC | 2004-07-01 | — | — | US | disclosed |