Arginine

SCHEMBL15323696

CC(C)C[C@H](N)C(=O)[O-].C[N+](C)(C)CCO.C[N+](C)(C)CCO.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)[O-].OCC(O)CO

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	NPY4R	P50391	7/20	0.33

▸	NPY1R	P25929	5/20	0.33

▸	NPY2R	P49146	4/20	0.33

▸	NPY5R	Q15761	4/20	0.33

▸	OTC	P00480	1/20	0.31

▸	SLC7A5	Q01650	1/20	0.30

▸	ANPEP	P15144	2/20	0.30

▸	RNPEP	Q9H4A4	2/20	0.30

▸	DNPEP	Q9ULA0	1/20	0.30

▸	DDAH1	O94760	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Arginine SCHEMBL15322645	0.96	NPY4R (0.34)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15323542	0.94	NPY4R (0.33)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15322388	0.92	OTC (0.35)	OTCDDAH1
Arginine SCHEMBL15323691	0.91	SLC7A5 (0.35)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15324001	0.91	OTC (0.34)	OTCDDAH1
Arginine SCHEMBL15322644	0.91	SLC7A5 (0.38)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15323071	0.90	NPY4R (0.35)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15323541	0.89	SLC7A5 (0.37)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15324404	0.89	NPY4R (0.35)	NPY4RNPY1RNPY2RNPY5ROTC
Arginine SCHEMBL15323425	0.86	OTC (0.35)	NPY4RNPY1RNPY2RNPY5ROTC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2836833-A1	PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18	Wayne State University (US)	2015-02-18	—	—	EP	disclosed
WO-2013155456-A1	PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18	WAYNE STATE UNIVERSITY (US)	2013-10-17	—	—	WO	disclosed