Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 11/20 | 0.35 |
| ▸ | NPY1R | P25929 | 6/20 | 0.35 |
| ▸ | NPY2R | P49146 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | OTC | P00480 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.33 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL15323071 | 0.99 | NPY4R (0.35) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15323542 | 0.94 | NPY4R (0.33) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15324119 | 0.94 | NPY4R (0.38) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Arginine SCHEMBL15324401 | 0.93 | SLC7A5 (0.41) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15323068 | 0.93 | SLC7A5 (0.41) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15322645 | 0.92 | NPY4R (0.34) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15324118 | 0.90 | SLC7A5 (0.43) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15322938 | 0.90 | OTC (0.35) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL15323696 | 0.89 | NPY4R (0.33) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL15322679 | 0.88 | OTC (0.39) | NPY4RNPY1RNPY2RNPY5ROTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |