Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3108985 | 0.99 | SLC6A9 (0.42) | SLC6A9NPY5RMAOBTAAR1TRPV1 | |
| SCHEMBL15324095 | 0.90 | SLC6A9 (0.40) | SLC6A9NPY5RMAOBTAAR1HTR1A | |
| Hydrochloric Acid SCHEMBL3100989 | 0.89 | SLC6A9 (0.40) | SLC6A9NPY5RMAOBTAAR1 | |
| SCHEMBL15324603 | 0.89 | SLC6A9 (0.43) | SLC6A9NPY5RTRPV1HTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL3105638 | 0.88 | SLC6A9 (0.42) | SLC6A9NPY5RTRPV1HTR1AHTR1D | |
| SCHEMBL15324092 | 0.85 | SLC6A9 (0.41) | SLC6A9NPY5RTRPV1 | |
| SCHEMBL17772405 | 0.85 | TAAR1 (0.43) | SLC6A9NPY5RMAOBTAAR1 | |
| Hydrochloric Acid SCHEMBL3100983 | 0.85 | SLC6A9 (0.40) | SLC6A9NPY5RTRPV1 | |
| SCHEMBL15323973 | 0.84 | DRD3 (0.42) | SLC6A9NPY5RMAOBTRPV1 | |
| Hydrochloric Acid SCHEMBL3108978 | 0.83 | DRD3 (0.41) | SLC6A9NPY5RMAOBTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396296-B1 | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND (DE) | 2016-05-25 | — | — | EP | claimed |
| US-9067871-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-30 | — | — | US | claimed |
| US-8563617-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2013-10-22 | — | — | US | claimed |