Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 11/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3101428 | 0.99 | SLC6A9 (0.57) | SLC6A9MAOBKDM4ES1PR1S1PR5 | |
| SCHEMBL15324086 | 0.87 | SLC6A9 (0.46) | SLC6A9MAOB | |
| Hydrochloric Acid SCHEMBL3099185 | 0.87 | SLC6A9 (0.45) | SLC6A9MAOB | |
| SCHEMBL15324249 | 0.86 | SLC6A9 (0.53) | SLC6A9 | |
| SCHEMBL3094433 | 0.85 | SLC6A9 (0.56) | SLC6A9HTT | |
| SCHEMBL15324105 | 0.85 | SLC6A9 (0.62) | SLC6A9MAOB | |
| Hydrochloric Acid SCHEMBL3105970 | 0.85 | SLC6A9 (0.52) | SLC6A9 | |
| Hydrochloric Acid SCHEMBL3101438 | 0.85 | SLC6A9 (0.61) | SLC6A9MAOB | |
| Hydrochloric Acid SCHEMBL3105797 | 0.85 | SLC6A9 (0.55) | SLC6A9HTT | |
| SCHEMBL3101504 | 0.81 | SLC6A9 (0.65) | SLC6A9S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396296-B1 | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND (DE) | 2016-05-25 | — | — | EP | claimed |
| US-9067871-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-30 | — | — | US | claimed |
| US-8563617-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2013-10-22 | — | — | US | claimed |