Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.33 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL15324188 | 1.00 | PRCP (0.36) | PRCPDPP7TET2KDM4AKDM4C | |
| Proline SCHEMBL15322873 | 0.94 | PRCP (0.39) | PRCPDPP7DPP4DPP8DPP9 | |
| Proline SCHEMBL8462550 | 0.82 | MEN1 (0.44) | PRCPDPP4DPP8DPP9MEN1 | |
| Succinic Acid SCHEMBL8462554 | 0.82 | MEN1 (0.44) | PRCPDPP4DPP8DPP9MEN1 | |
| Proline SCHEMBL15324190 | 0.81 | DPP7 (0.34) | PRCPDPP7TLR2 | |
| Succinic Acid SCHEMBL15322642 | 0.81 | PRCP (0.39) | PRCPDPP7DPP4DPP8DPP9 | |
| Proline SCHEMBL15322641 | 0.81 | PRCP (0.39) | PRCPDPP7DPP4DPP8DPP9 | |
| Proline SCHEMBL599790 | 0.79 | FFAR3 (0.46) | PRCPDPP7DPP4DPP8DPP9 | |
| Proline SCHEMBL599791 | 0.79 | FFAR3 (0.46) | PRCPDPP7DPP4DPP8DPP9 | |
| Succinic Acid SCHEMBL15322394 | 0.78 | ACE (0.32) | PRCPDPP7DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |