Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL15324191 | 0.94 | PRCP (0.36) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL15324188 | 0.94 | PRCP (0.36) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL2228243 | 0.83 | MEN1 (0.47) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL2228246 | 0.83 | MEN1 (0.47) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL29811219 | 0.83 | MEN1 (0.47) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL1740644 | 0.80 | TP53 (0.42) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL1740645 | 0.80 | TP53 (0.42) | PRCPDPP7MEN1KMT2ABLM | |
| Proline SCHEMBL28015156 | 0.80 | MEN1 (0.41) | PRCPDPP7MEN1KMT2ABLM | |
| Isoleucine SCHEMBL3692758 | 0.80 | DPP4 (0.39) | PRCPDPP7DPP4DPP8DPP9 | |
| Isoleucine SCHEMBL3692760 | 0.80 | DPP4 (0.39) | PRCPDPP7DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |