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Arginine

Arginine

SCHEMBL15324207

CC(=O)O.CC(=O)O.C[C@@H](O)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.C[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.O=C(O)CCC(=O)O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ OTC P00480 1/20 0.39
▸ NOS2 P35228 6/20 0.37
▸ NOS1 P29475 6/20 0.37
▸ NOS3 P29474 4/20 0.37
▸ DDAH1 O94760 2/20 0.37
▸ CYP1A2 P05177 2/20 0.36
▸ GRM8 O00222 1/20 0.36
▸ GRM6 O15303 1/20 0.36
▸ GRIN2D O15399 1/20 0.36
▸ GRIN3B O60391 1/20 0.36
▸ GSR P00390 1/20 0.36
▸ GRIK1 P39086 1/20 0.36
▸ GRM5 P41594 1/20 0.36
▸ GRIA1 P42261 1/20 0.36
▸ GRIA2 P42262 1/20 0.36
▸ GRIA3 P42263 1/20 0.36
▸ SLC1A3 P43003 1/20 0.36
▸ SLC1A2 P43004 1/20 0.36
▸ SLC1A1 P43005 1/20 0.36
▸ GRIA4 P48058 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL15324206 1.00 OTC (0.39) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL20996120 0.90 OTC (0.46) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL3898452 0.90 OTC (0.46) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL1965664 0.90 OTC (0.46) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL27842844 0.90 OTC (0.46) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL31571149 0.89 OTC (0.47) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL2762369 0.88 OTC (0.42) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL15323426 0.87 OTC (0.48) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL15323423 0.87 OTC (0.48) OTCNOS2NOS1NOS3DDAH1
Arginine SCHEMBL11018148 0.87 OTC (0.48) OTCNOS2NOS1NOS3DDAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2836832-A1 EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA Wayne State University (US) 2015-02-18 — — EP disclosed
WO-2013155458-A1 EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA WAYNE STATE UNIVERSITY (US) 2013-10-17 — — WO disclosed