Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | NOS1 | P29475 | 7/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL3898452 | 1.00 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL20996120 | 1.00 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27842844 | 1.00 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL2762369 | 0.95 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL28793887 | 0.93 | SLC7A5 (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27580278 | 0.93 | OTC (0.41) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL28808826 | 0.91 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL1964085 | 0.91 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15324206 | 0.90 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15324207 | 0.90 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110337287-A | The stabilization formulations of interferon beta variant | 瑷备恩有限公司 | 2019-10-15 | — | — | CN | claimed |
| CN-102220299-A | Feruloyl esterase A mutant and application thereof | CHENGDU INST BIOLOGY CAS | 2011-10-19 | — | — | CN | claimed |
| US-10633422-B2 | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA | WISCONSIN ALUMNI RESEARCH FOUNDATION (WARF) (US) | 2020-04-28 | — | — | US | disclosed |
| US-20160355790-A1 | INFLUENZA VIRUS REPLICATION BY INHIBITING MICRORNA LEC7C BINDING TO INFLUENZA VIRAL CRNA AND MRNA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | disclosed |
| CN-105849262-A | Anti-LPS 011 antibody | 第三共株式会社 | 2016-08-10 | — | — | CN | disclosed |
| WO-2011072264-A2 | METHODS AND COMPOSITIONS FOR BIOMASS TREATMENT | QTEROS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| EP-1589096-B1 | Method for producing L-amino acid | AJINOMOTO KK (JP) | 2010-03-17 | — | — | EP | disclosed |
| EP-1016710-B1 | Method for producing L-amino acids | AJINOMOTO KK (JP) | 2010-03-17 | — | — | EP | disclosed |
| EP-1580262-B1 | Method for producing L-amino acid | AJINOMOTO KK (JP) | 2010-01-27 | — | — | EP | disclosed |
| US-7544469-B2 | Methods and compositions for optical detection of single-stranded polynucleotides | THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 2009-06-09 | — | — | US | disclosed |
| US-20090011404-A9 | Methods and compositions for optical detection of single-stranded polynucleotides | UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 2009-01-08 | — | — | US | disclosed |
| US-20070178455-A1 | Methods and compositions for optical detection of single-stranded polynucleotides | UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 2007-08-02 | — | — | US | disclosed |