Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.35 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.35 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.35 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3105742 | 0.99 | SLC6A9 (0.47) | SLC6A9TRPV1NPY5RPDE4BPLAAT3 | |
| SCHEMBL3099970 | 0.90 | SLC6A9 (0.49) | SLC6A9TRPV1NPY5RPDE4B | |
| SCHEMBL3099975 | 0.87 | SLC6A9 (0.49) | SLC6A9TRPV1NPY5RTAAR1 | |
| SCHEMBL15324304 | 0.86 | SLC6A9 (0.46) | SLC6A9TRPV1PDE4B | |
| SCHEMBL15324320 | 0.85 | SLC6A9 (0.48) | SLC6A9TRPV1NPY5RTAAR1 | |
| Hydrochloric Acid SCHEMBL3092876 | 0.85 | SLC6A9 (0.45) | SLC6A9TRPV1PDE4B | |
| Hydrochloric Acid SCHEMBL3105749 | 0.84 | SLC6A9 (0.47) | SLC6A9TRPV1NPY5RTAAR1 | |
| SCHEMBL15324092 | 0.79 | SLC6A9 (0.41) | SLC6A9TRPV1NPY5RFFAR1 | |
| SCHEMBL7898852 | 0.79 | SLC6A9 (0.67) | SLC6A9TRPV1NPY5RTAAR1 | |
| Hydrochloric Acid SCHEMBL3100983 | 0.79 | SLC6A9 (0.40) | SLC6A9TRPV1NPY5RFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396296-B1 | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND (DE) | 2016-05-25 | — | — | EP | claimed |
| US-9067871-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-30 | — | — | US | claimed |
| US-8563617-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2013-10-22 | — | — | US | claimed |