Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194838 | 0.89 | MAPT (0.66) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL15323510 | 0.86 | GAA (0.64) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL15317657 | 0.80 | ALDH1A1 (0.89) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL17886709 | 0.77 | ALDH1A1 (0.53) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL3324221 | 0.77 | MAPT (0.57) | MAPTSMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL13135919 | 0.77 | HSD17B10 (0.61) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL15317690 | 0.76 | MAPK1 (0.59) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL13115896 | 0.76 | HSD17B10 (0.58) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL15317635 | 0.75 | HSD17B10 (0.65) | SMN1; SMN2ALDH1A1GAARAB9AHSD17B10 | |
| SCHEMBL11916163 | 0.75 | HSD17B10 (0.65) | SMN1; SMN2ALDH1A1GAARAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | NFATC1, IL5, CD4 | MAPT 2022/4885SMN1; SMN2 3843/4885LMNA 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.