Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942852 | 1.00 | MAPT (0.50) | MAPTGBA1SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL5371008 | 1.00 | MAPT (0.50) | MAPTGBA1SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL10130060 | 1.00 | MAPT (0.50) | MAPTGBA1SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL17652536 | 0.85 | GBA1 (0.50) | MAPTGBA1SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL20734689 | 0.84 | SIGMAR1 (0.55) | MAPTGBA1SIGMAR1FUCA1 | |
| SCHEMBL1872881 | 0.84 | GBA1 (0.56) | MAPTGBA1SIGMAR1ALDH1A1 | |
| SCHEMBL2921408 | 0.84 | GBA1 (0.56) | MAPTGBA1SIGMAR1ALDH1A1 | |
| SCHEMBL2921412 | 0.84 | GBA1 (0.56) | MAPTGBA1SIGMAR1ALDH1A1 | |
| SCHEMBL14038173 | 0.83 | PNP (0.38) | MAPTGBA1SIGMAR1HDAC11 | |
| SCHEMBL24938856 | 0.82 | MAPT (0.53) | MAPTGBA1SIGMAR1HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014032188-A1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2014-03-06 | — | — | WO | disclosed |
| WO-2013149362-A1 | 1-(DIHYDRONAPHTHALENYL)PYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2013-10-10 | — | — | WO | disclosed |