Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15307252 | 0.82 | CLK2 (0.42) | — | |
| SCHEMBL15365948 | 0.81 | MAPT (0.39) | MAPTALDH1A1HTTRAB9ANPSR1 | |
| SCHEMBL15365445 | 0.80 | MAP4K4 (0.45) | MAPT | |
| SCHEMBL19678629 | 0.77 | CSNK1D (0.43) | MAPTRAB9A | |
| SCHEMBL30143698 | 0.75 | CLK2 (0.40) | ALDH1A1NPSR1 | |
| SCHEMBL15322335 | 0.75 | MAPT (0.30) | MAPT | |
| SCHEMBL15301947 | 0.75 | CLK2 (0.40) | ALDH1A1NPSR1 | |
| SCHEMBL15365950 | 0.71 | MAPT (0.36) | MAPTALDH1A1HTTRAB9A | |
| SCHEMBL4457346 | 0.68 | MAPT (0.50) | MAPTALDH1A1HTTNPSR1 | |
| SCHEMBL13482304 | 0.67 | MAPT (0.40) | MAPTALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013151708-A1 | INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2013-10-10 | — | — | WO | disclosed |