Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184621 | 0.86 | RAB9A (0.52) | HDAC8FFAR1NPC1RAB9APOLB | |
| SCHEMBL21644545 | 0.86 | HDAC8 (0.46) | HDAC8FFAR1NPC1RAB9APOLB | |
| SCHEMBL20509060 | 0.82 | PDE4A (0.57) | HDAC8NPC1RAB9ASMN1; SMN2TNFRSF1A | |
| SCHEMBL30779569 | 0.82 | PDE4A (0.57) | HDAC8NPC1RAB9ASMN1; SMN2TNFRSF1A | |
| SCHEMBL20509709 | 0.82 | PDE4A (0.60) | POLBTNFRSF1AMAPTALDH1A1HTT | |
| SCHEMBL30779625 | 0.82 | PDE4A (0.60) | POLBTNFRSF1AMAPTALDH1A1HTT | |
| SCHEMBL15326013 | 0.81 | FFAR1 (0.44) | HDAC8FFAR1NPC1RAB9APOLB | |
| SCHEMBL30779641 | 0.79 | NPC1 (0.48) | HDAC8NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL15320729 | 0.79 | NPC1 (0.48) | HDAC8NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL15320842 | 0.75 | HDAC8 (0.46) | HDAC8FFAR1NPC1RAB9AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119395-A1 | NOVEL TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. | 2015-04-30 | — | — | US | disclosed |
| WO-2013152206-A1 | NOVEL TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2013-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119395-A1 | NOVEL TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | HSP90AB1, HSP90AA1, HSP90AB2P | HDAC8 49/4885FFAR1 4757/4885NPC1 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.