Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 20/20 | 0.50 |
| ▸ | CTSB | P07858 | 18/20 | 0.46 |
| ▸ | CTSS | P25774 | 18/20 | 0.46 |
| ▸ | CTSK | P43235 | 18/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3066987 | 1.00 | CTSL (0.50) | CTSLCTSBCTSSCTSK | |
| SCHEMBL15327141 | 1.00 | CTSL (0.50) | CTSLCTSBCTSSCTSK | |
| SCHEMBL696145 | 0.85 | CTSL (0.71) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3079102 | 0.83 | CTSL (0.44) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3065724 | 0.82 | CTSL (0.49) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3074107 | 0.81 | CTSL (0.50) | CTSLCTSBCTSSCTSK | |
| SCHEMBL15327816 | 0.80 | CTSL (0.52) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3062344 | 0.80 | CTSL (0.52) | CTSLCTSBCTSSCTSK | |
| SCHEMBL14973560 | 0.78 | CTSL (0.73) | CTSLCTSBCTSSCTSK | |
| SCHEMBL2104359 | 0.78 | CTSL (0.74) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | disclosed |