Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.30 |
| ▸ | MMP1 | P03956 | 2/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP3 | P08254 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230175 | 0.72 | PDE4D (0.38) | CTSLPDE4D | |
| SCHEMBL13351589 | 0.72 | PDE4D (0.38) | CTSLPDE4D | |
| SCHEMBL13351557 | 0.72 | PDE4D (0.38) | CTSLPDE4D | |
| SCHEMBL25946312 | 0.70 | CCNE1 (0.35) | CTSLPDE4D | |
| SCHEMBL31629517 | 0.70 | CCNE1 (0.35) | CTSLPDE4D | |
| SCHEMBL7109527 | 0.69 | TSHR (0.40) | — | |
| SCHEMBL29830733 | 0.69 | PDE4D (0.45) | PDE4D | |
| SCHEMBL25394555 | 0.69 | CTSL (0.38) | CTSLPDE4D | |
| SCHEMBL3839876 | 0.69 | CTSL (0.38) | CTSLPDE4D | |
| SCHEMBL3999275 | 0.69 | CTSL (0.38) | CTSLPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |