Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | EEF2K | O00418 | 2/20 | 0.42 |
| ▸ | EEF2 | P13639 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL707780 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL574665 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL1330666 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL15329021 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL5077207 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL1330853 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL3835039 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL15329258 | 0.98 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| SCHEMBL3309595 | 0.98 | CA1 (0.58) | CA1CA2KMT2AMEN1EEF2K | |
| SCHEMBL5287243 | 0.96 | CA1 (0.61) | CA1CA2KMT2AMEN1EEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190111423-A1 | DEVICES AND METHODS FOR AUTONOMOUS MEASUREMENTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-04-18 | — | — | US | disclosed |
| US-10207269-B2 | System and method for movement and timing control | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-02-19 | — | — | US | disclosed |
| US-10184697-B2 | Device for cooling fluid, method for cooling fluid | UCHICAGO ARGONNE, LLC (US) | 2019-01-22 | — | — | US | disclosed |
| EP-2839260-B1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | TALIS BIOMEDICAL CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| US-9822356-B2 | Fluidic devices and systems for sample preparation or autonomous analysis | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-21 | — | — | US | disclosed |
| US-9808798-B2 | Fluidic devices for biospecimen preservation | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-07 | — | — | US | disclosed |
| US-9803237-B2 | Slip-induced compartmentalization | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-10-31 | — | — | US | disclosed |
| US-20170082324-A1 | DEVICE FOR COOLING FLUID, METHOD FOR COOLING FLUID | UCHICAGO ARGONNE, LLC. (US) | 2017-03-23 | — | — | US | disclosed |
| US-20160263577-A1 | SYSTEM AND METHOD FOR MOVEMENT AND TIMING CONTROL | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-09-15 | — | — | US | disclosed |
| EP-3046663-A2 | SYSTEM AND METHOD FOR MOVEMENT AND TIMING CONTROL | California Institute of Technology (US) | 2016-07-27 | — | — | EP | disclosed |
| WO-2016105508-A2 | DEVICES AND METHODS FOR AUTONOMOUS MEASUREMENTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-06-30 | — | — | WO | disclosed |
| EP-2839260-A1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | Slipchip, LLC (US) | 2015-02-25 | — | — | EP | disclosed |
| US-20130309679-A1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2013159116-A1 | FLUIDIC DEVICES FOR BIOSPECIMEN PRESERVATION | UNIVERSITY OF CHICAGO (US) | 2013-10-24 | — | — | WO | disclosed |
| WO-2013159117-A1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | SlipChip, LLC (US) | 2013-10-24 | — | — | WO | disclosed |
| US-20130281316-A1 | SLIP-INDUCED COMPARTMENTALIZATION | SlipChip, LLC (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130280725-A1 | FLUIDIC DEVICES FOR BIOSPECIMEN PRESERVATION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-10-24 | — | — | US | disclosed |