Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1261496 | 0.86 | NOTUM (0.60) | NOTUMMCHR1AKR1C3 | |
| SCHEMBL3552341 | 0.83 | MAPT (0.50) | — | |
| SCHEMBL3551943 | 0.83 | MAPT (0.50) | — | |
| SCHEMBL2437816 | 0.82 | LSS (0.43) | NOTUMMCHR1LSS | |
| SCHEMBL22499839 | 0.81 | NOTUM (0.64) | NOTUM | |
| SCHEMBL22499840 | 0.81 | NOTUM (0.64) | NOTUM | |
| SCHEMBL16398200 | 0.80 | MCHR1 (0.40) | NOTUMMCHR1 | |
| SCHEMBL22499863 | 0.79 | HRH3 (0.48) | NOTUMMCHR1 | |
| SCHEMBL22499861 | 0.79 | HRH3 (0.48) | NOTUMMCHR1 | |
| SCHEMBL22499946 | 0.79 | NOTUM (0.54) | NOTUMAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035143-A2 | METHODS AND COMPOSITIONS FOR INHIBITING RHO-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-03-24 | — | — | WO | disclosed |