Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 12/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588201 | 0.86 | NR1H2 (0.62) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL3584666 | 0.84 | NR1H2 (0.54) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL15344605 | 0.83 | NR1H2 (0.49) | RXRANR1H2NR1H3PTGS2HSD11B1 | |
| SCHEMBL3575840 | 0.82 | RXRA (0.51) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL3579036 | 0.80 | NR1H2 (0.61) | RXRANR1H2NR1H3PTGS2HSD11B1 | |
| SCHEMBL3576062 | 0.80 | NR1H2 (0.76) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL3586673 | 0.80 | RXRA (0.62) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL3580463 | 0.79 | NR1H2 (0.60) | RXRANR1H2NR1H3PTGS2HSD11B1 | |
| SCHEMBL14621199 | 0.79 | RXRA (0.64) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL3583381 | 0.79 | NR1H2 (0.51) | RXRANR1H2NR1H3PTGS2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569352-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2013-10-29 | — | — | US | claimed |