Sugi Predict

Sugi Predict / Compounds / SCHEMBL1534489

SCHEMBL1534489

SCHEMBL1534489

NC1(c2ccc(-c3c(-c4ccccc4)oc4cc5c(cc4c3=O)OCCO5)cc2)CCC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLA2G2A P14555 1/20 0.42
▸ PLA2G4A P47712 1/20 0.42
▸ NPC1 O15118 2/20 0.42
▸ RAB9A P51151 2/20 0.42
▸ AKT1 P31749 12/20 0.41
▸ USP2 O75604 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ MAPK10 P53779 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ MAPK14 Q16539 1/20 0.38
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ AKT2 P31751 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1534703 0.85 PLA2G2A (0.44) PLA2G2APLA2G4AAKT1MAPK14MEN1
SCHEMBL1534318 0.83 PLA2G2A (0.57) PLA2G2APLA2G4AAKT1ALDH1A1LMNA
SCHEMBL12677028 0.83 PLA2G2A (0.57) PLA2G2APLA2G4AAKT1ALDH1A1LMNA
SCHEMBL1534656 0.83 PLA2G2A (0.46) PLA2G2APLA2G4AAKT1ALDH1A1MAPT
SCHEMBL1534675 0.83 MAPK14 (0.47) PLA2G2APLA2G4AAKT1MAPK14AKT2
SCHEMBL1534389 0.83 MAPK14 (0.47) PLA2G2APLA2G4AAKT1MAPK14AKT2
SCHEMBL1534562 0.82 MEN1 (0.45) PLA2G2APLA2G4ANPC1AKT1ALDH1A1
SCHEMBL1534566 0.82 PLA2G2A (0.42) PLA2G2APLA2G4AAKT1MEN1KMT2A
Hydrochloric Acid SCHEMBL1898880 0.82 PLA2G2A (0.56) PLA2G2APLA2G4AAKT1ALDH1A1LMNA
SCHEMBL1534564 0.82 MAPT (0.46) PLA2G2APLA2G4AAKT1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546376-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2013-10-01 — — US claimed
US-20120238541-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2012-09-20 — — US claimed
US-8546376-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2013-10-01 — — US disclosed
US-8546376-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2013-10-01 — — US disclosed
US-8546376-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2013-10-01 — — US disclosed
US-20120238541-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2012-09-20 — — US disclosed
US-20120238541-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2012-09-20 — — US disclosed
US-20120238541-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2012-09-20 — — US disclosed
EP-2473495-A1 PHARMACEUTICAL COMPOUNDS Almac Discovery Limited (GB) 2012-07-11 — — EP disclosed
WO-2011033265-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2011-03-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120238541-A1 PHARMACEUTICAL COMPOUNDS PIK3CA, PLK1, MTOR PLA2G2A 2537/4885PLA2G4A 2025/4885NPC1 835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.