Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 8/20 | 0.43 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | MLLT1 | Q03111 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17448337 | 1.00 | PDE1C (0.43) | PDE1CKDM1AMLLT1PDE2APDE5A | |
| SCHEMBL17448338 | 1.00 | PDE1C (0.43) | PDE1CKDM1AMLLT1PDE2APDE5A | |
| SCHEMBL19905905 | 0.85 | PDE1C (0.40) | PDE1CKDM1APDE2APDE5ACYP2C9 | |
| SCHEMBL25248916 | 0.81 | PDE1C (0.38) | PDE1CKDM1AAPPMAOBDRD4 | |
| SCHEMBL15345087 | 0.78 | PDE1C (0.42) | PDE1CKDM1AMLLT1PDE2APDE5A | |
| SCHEMBL15345135 | 0.78 | PDE1C (0.42) | PDE1CKDM1AMLLT1PDE2APDE5A | |
| SCHEMBL15345080 | 0.78 | PDE1C (0.42) | PDE1CKDM1AMLLT1PDE2APDE5A | |
| SCHEMBL15333797 | 0.78 | PDE1C (0.44) | PDE1CKDM1AMLLT1PDE2APDE5A | |
| SCHEMBL6745850 | 0.78 | PTGER3 (0.37) | PDE1CKDM1ABRD4CREBBP | |
| SCHEMBL15344928 | 0.77 | PDE1C (0.44) | PDE1CKDM1APDE2APDE5ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-01-21 | — | — | US | disclosed |
| US-8987250-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | PDE1C 4803/4885KDM1A 4401/4885MLLT1 718/4885 |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | PDE1C 4803/4885KDM1A 4401/4885MLLT1 718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.