Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15342745 | 0.84 | GRM5 (0.38) | PIK3CAPIK3CBPIK3CGGRM5CYP11B1 | |
| SCHEMBL15345146 | 0.81 | MTOR (0.45) | PIK3CAPIK3CBPIK3CGGRM5LRRK2 | |
| SCHEMBL15345169 | 0.78 | GRM5 (0.50) | CCR1CCR5CCR8GRM5METAP2 | |
| SCHEMBL15345191 | 0.78 | CCR1 (0.47) | CCR1CCR5CCR8PIK3CAPIK3CB | |
| SCHEMBL7940326 | 0.76 | GRM5 (0.41) | PIK3CAPIK3CBPIK3CGGRM5CYP11B1 | |
| SCHEMBL15345147 | 0.74 | CYP11B1 (0.57) | CCR1CCR5CCR8GRM5METAP2 | |
| SCHEMBL15345180 | 0.73 | CCR1 (0.41) | CCR1CCR5CCR8PIK3CAPIK3CB | |
| SCHEMBL25029143 | 0.71 | GRM5 (0.40) | PIK3CAPIK3CBPIK3CGGRM5CYP11B1 | |
| SCHEMBL29658910 | 0.71 | GRM5 (0.40) | PIK3CAPIK3CBPIK3CGGRM5CYP11B1 | |
| SCHEMBL29364626 | 0.71 | GRM5 (0.40) | PIK3CAPIK3CBPIK3CGGRM5CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | CCR1 106/4885CCR5 3/4885CCR8 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.