Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15375592 | 1.00 | CA14 (0.41) | CA14CA12NOS1NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL3023545 | 0.98 | CA14 (0.40) | CA14CA12NOS1NOS3NOS2 | |
| SCHEMBL3240752 | 0.85 | NOS1 (0.41) | CA14CA12NOS1NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL28773975 | 0.83 | NOS1 (0.41) | CA14CA12NOS1NOS3NOS2 | |
| SCHEMBL13613724 | 0.83 | CA14 (0.46) | CA14CA12NOS1NOS3NOS2 | |
| SCHEMBL12281961 | 0.83 | CA14 (0.46) | CA14CA12NOS1NOS3NOS2 | |
| SCHEMBL15156959 | 0.83 | SMN1; SMN2 (0.42) | CA14CA12SMN1; SMN2CA1CA2 | |
| SCHEMBL28902221 | 0.83 | SMN1; SMN2 (0.42) | CA14CA12SMN1; SMN2CA1CA2 | |
| SCHEMBL27457895 | 0.82 | SLC7A5 (0.44) | CA14CA12NOS1NOS3NOS2 | |
| SCHEMBL15268524 | 0.79 | NOS1 (0.39) | CA14CA12NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170814-B1 | ANTIBACTERIAL AGENTS | ACHAOGEN INC (US) | 2016-08-17 | — | — | EP | disclosed |
| EP-2662353-A2 | Antibacterial agents | Achaogen, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |