Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631112 | 0.81 | HTR6 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL19953539 | 0.81 | HTR6 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL3047034 | 0.81 | HTR6 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL19182923 | 0.81 | HTR6 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL6631116 | 0.81 | HTR6 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL24065055 | 0.81 | HTR6 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL16866691 | 0.81 | HTR2A (0.47) | IDO1PDPK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4199739 | 0.80 | KDM1A (0.46) | IDO1ANPEP | |
| Hydrochloric Acid SCHEMBL31324603 | 0.80 | KDM1A (0.46) | IDO1ANPEP | |
| SCHEMBL14065441 | 0.80 | IDO1 (0.46) | IDO1PDPK1PIN1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11060072-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-10947572-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190345458-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2019-11-14 | — | — | US | disclosed |
| US-10407668-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180030419-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2018-02-01 | — | — | US | disclosed |
| US-9296993-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9193957-B2 | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds | CODEXIS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20130302859-A1 | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. | CODEXIS,INC. (US) | 2013-11-14 | — | — | US | disclosed |