Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL1538021 | 0.94 | ALOX15 (0.40) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| Succinic Acid SCHEMBL1414629 | 0.82 | CYP1A2 (0.50) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| Succinic Acid SCHEMBL1538063 | 0.82 | ALOX15 (0.38) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| SCHEMBL65889 | 0.80 | ALOX15 (0.59) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| Benzene SCHEMBL10638262 | 0.80 | ALOX15 (0.59) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| Phosphine SCHEMBL3135561 | 0.78 | ALOX15 (0.57) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| Ammonia Solution, Strong SCHEMBL3299235 | 0.78 | ALOX15 (0.57) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| SCHEMBL812165 | 0.78 | ALOX15 (0.57) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| SCHEMBL3781304 | 0.78 | ALOX15 (0.57) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 | |
| Phosphine SCHEMBL3820807 | 0.78 | ALOX15 (0.57) | ALOX15ALDH1A1HSD17B10HPGDCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1792941-B1 | RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME | TORAY INDUSTRIES (JP) | 2011-05-18 | — | — | EP | disclosed |
| US-20110071247-A1 | RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME | TORAY INDUSTRIES, INC. (JP) | 2011-03-24 | — | — | US | disclosed |
| US-7863382-B2 | Resin composition and molded article comprising the same | Toray Industriés, Inc. (JP) | 2011-01-04 | — | — | US | disclosed |