Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK17 | Q00537 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5078796 | 0.86 | TBK1 (0.41) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5634235 | 0.86 | JAK3 (0.38) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5078782 | 0.86 | TBK1 (0.41) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5141329 | 0.85 | AXL (0.36) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5141330 | 0.85 | AXL (0.36) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5074726 | 0.84 | JAK3 (0.40) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5077837 | 0.84 | JAK3 (0.40) | TBK1JAK3PLK4JAK2ROCK2 | |
| SCHEMBL5634991 | 0.84 | JAK3 (0.51) | JAK3PLK4JAK2ROCK2STK10 | |
| SCHEMBL5074758 | 0.84 | JAK3 (0.51) | JAK3PLK4JAK2ROCK2STK10 | |
| SCHEMBL5074742 | 0.84 | JAK3 (0.51) | JAK3PLK4JAK2ROCK2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580802-B2 | Pyrrolo[2,3-D]pyrimidines as inhibitors of Janus kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-11-12 | — | — | US | disclosed |
| US-8580802-B2 | Pyrrolo[2,3-D]pyrimidines as inhibitors of Janus kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-11-12 | — | — | US | disclosed |