Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 14/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.39 |
| ▸ | DLK1 | P80370 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15399039 | 1.00 | MAP3K12 (0.44) | MAP3K12MTORPIK3CAMAP3K13DLK1 | |
| SCHEMBL19221771 | 1.00 | MAP3K12 (0.44) | MAP3K12MTORPIK3CAMAP3K13DLK1 | |
| SCHEMBL25889732 | 0.83 | MAP3K12 (0.39) | MAP3K12MTORPIK3CAMAP3K13DLK1 | |
| SCHEMBL30206581 | 0.83 | MAP3K12 (0.39) | MAP3K12MTORPIK3CAMAP3K13DLK1 | |
| SCHEMBL25889731 | 0.83 | MAP3K12 (0.39) | MAP3K12MTORPIK3CAMAP3K13DLK1 | |
| SCHEMBL30206213 | 0.83 | MAP3K12 (0.39) | MAP3K12MTORPIK3CAMAP3K13DLK1 | |
| SCHEMBL12082429 | 0.83 | SOS1 (0.39) | MAP3K12MTORPIK3CASOS1PRKDC | |
| SCHEMBL21256819 | 0.83 | SOS1 (0.39) | MAP3K12MTORPIK3CASOS1PRKDC | |
| SCHEMBL21256815 | 0.83 | SOS1 (0.39) | MAP3K12MTORPIK3CASOS1PRKDC | |
| SCHEMBL18436556 | 0.82 | PRKDC (0.45) | MAP3K12MTORPIK3CAMAP3K13SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107393-A1 | TRICYCLIC COMPOUNDS | SCHRÖDINGER, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| WO-2023138362-A1 | WEE1 INHIBITOR, PREPARATION THEREFOR, AND USE THEREOF | 江苏天士力帝益药业有限公司 | 2023-07-27 | — | — | WO | disclosed |
| EP-2867238-B1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2017-08-09 | — | — | EP | disclosed |
| EP-2867238-B1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2017-08-09 | — | — | EP | disclosed |
| EP-2867238-A1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BioSciences Australia Pty Ltd (AU) | 2015-05-06 | — | — | EP | disclosed |
| US-8809359-B2 | Phenyl amino pyrimidine bicyclic compounds and uses thereof | YM BIOSCIENCES AUSTRALIA PTY LTD (US) | 2014-08-19 | — | — | US | disclosed |
| WO-2014000032-A1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2014-01-03 | — | — | WO | disclosed |
| US-20140005161-A1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY LTD (US) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005161-A1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | JAK3, JAK1, JAK2 | MAP3K12 66/4885MTOR 257/4885PIK3CA 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.